The Research Centers in Minority Institutions (RCMI) Center for Health Disparities Research (RCHDR) at Jackson State University (JSU) conducts innovative biomedical, behavioral, and or clinical research aimed at improving minority health and reducing or eliminating health disparities. Seven major components comprise the RCHDR; the Administrative Core (AC), Research Infrastructure Core (RIC), Investigator Development Core (IDC), Community Engagement Core (CEC), and three Research projects. The AC provides administrative and managerial oversight of all program activities. The RIC offers laboratory resources and technical expertise in new biomedical research technologies. The IDC provides funding opportunities aimed towards innovative Pilot projects conducted by early-stage investigators. The CEC fosters community engagement and research participation and facilitates the translation of research findings. The PIs of both Research and Pilot projects are conducting high-impact research that will lead to novel discoveries in the science of health disparities. The RCHDR creates an excellent research ecosystem that supports team science and maximizes research productivity. The RCHDR also catalyzes scientific findings on the underlying causes and mechanisms that result in health disparities and the efficient and cost-effective strategies for the prevention and control of health disparity diseases in Mississippi and the United States.