PULMONARY FIBROSIS REGULATION BY MIR-1

Fibrotic diseases are associated with high morbidity and mortality. Pulmonary fibrosis (PF) is a progressive disease with no effective treatment except a lung transplant.

We have previously reported increased ROS and activation of MAPK, NF-κB, and TGFβ in alveolar epithelial cells following treatment with known lung fibrotic toxicants silica and multi-walled carbon nanoparticles (MWCNT).

The proposed study will elucidate the cellular and molecular mechanism involved in lung fibrosis by targeting TSP-1 via miR-1.

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Maricica Pacurari, Ph.D. Associate Professor 601-979-3464 maricica.pacurari@jsums.edu